The College of Science and Medicine (CoSM) is led by the College Dean who has broad oversight of the academic activities conducted by, and between, the Schools comprising the College, and who chairs the College Executive Committee. The College's education programme is overseen by the Associate Dean (Education) who holds the delegation for all education-related matters within the College. Other Associate Deans oversee other aspects of the College's activities (see below).  The College General Manager has oversight of the administrative services provided by the College.

• Dean, Professor Kiaran Kirk
• Acting General Manager, Nancy Richardson 

The College of Science and Medicine has six Associate Deans, each undertaking the Associate Dean role on a fractional basis and overseeing a particular aspect of the College's activities:

• Associate Dean (Education), Assoc. Prof. Juliey Beckman, oversees, and holds formal delegation for, all education-related matters in the College, and chairs the College of Science and Medicine Education Committee.
• Associate Dean (Student Experience and Integrity), Dr Sara Rapson, works to support, reform and renew educational activities to ensure positive learning outcomes and experiences for students studying in the College.
• Associate Dean (Research, Infrastructure and Engagement), Prof. Francis Bennet, oversees College-level research initiatives, interfaces on behalf of the College with the Deputy Vice-Chancellor (Research and Innovation) portfolio, and chairs the College of Science and Medicine Research Committee.
• Associate Dean (Higher Degree Research;  HDR), Assoc. Prof. Tony Travouillon, oversees all matters relating to Higher Degree Research (PhD and MPhil) students based in the College, and chairs the College of Science and Medicine HDR Committee.
• Associate Dean (International), Prof. Sasha Mikheyev, oversees the College’s international strategy, including College-level partnerships with institutions overseas.
• Associate Dean (IDEA), Assoc. Prof. Anne Bruestle, oversees the College’s commitment to promoting and supporting inclusion, diversity, equity and access in our community.