Genomics sequencing has created opportunities and challenges to gain new insights in biology and biomedical research. Genome sequencing data usually consists of millions or billions of short DNA sequences, called reads, that are randomly drawn from genomes. Genome assembly is to put reads back together into a single genome, like solving a giant jigsaw puzzle. While genome assembly remains computationally challenging, metagenomics analysis aims to resolve the composition of a mixture of genomes, like solving mixed jigsaw puzzles simultaneously. In this masterclass, you will learn about computational models and algorithms to address these emerging challenges.